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Hydrochloric Acid → 4,5,6-Trimethoxy-2,3-dihydro-1H-inden-1-one

HRID 473067
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HRID 473067 반응식
[CH3:1][O:2][C:3]1[C:11]([O:12][CH3:13])=[C:10]([O:14][CH3:15])[CH:9]=[C:8]2[C:4]=1[CH:5](C1C=C(OC)C(OC)=C(OC)C=1)[CH2:6][C:7]2=[O:16].C(=O)([O-])[O-].[K+].[K+].C1OC2C=CC(C=O)=CC=2O1.Cl>O>[CH3:1][O:2][C:3]1[C:11]([O:12][CH3:13])=[C:10]([O:14][CH3:15])[CH:9]=[C:8]2[C:4]=1[CH2:5][CH2:6][C:7]2=[O:16]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8438PiperonalHCID 11430Potassium CarbonateHCID 24894048HCID 24894048, 화합물2회

생성물 1

HCID 190217004,5,6-Trimethoxy-2,3-dihydro-1H-inden-1-one수율 144%

시약·촉매·용매 1

HCID 962Water용매

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온도
30 °C

실험 절차

4,5,6-trimethoxy-3-(3,4,5-trimethoxyphenyl)-indan-1-one (formula 7, 250 mg) was taken in 5% aqueous-methanolic (1:3) potassium carbonate (10 mL). To this stirred solution 3,4-methylenedioxybenzaldehyde (100 mg) was added and further stirred at room temperature at 30° C. for 1 hour. On completion, the reaction mixture was diluted with water, acidified with dil. HCl and extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous sodium sulphate and evaporated to get a residue. The residue was purified through silica gel column to get 2-benzo[1,3]dioxo-5-ylmethylene-4,5,6-trimethoxy-3-(3,4,5-trimethoxyphenyl)-indan-1-one (formula 8, 206 mg)

후처리

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water
  3. dry with materialdried over anhydrous sodium sulphate
  4. customevaporated
  5. customto get a residue
  6. customThe residue was purified through silica gel column

출처 및 근거

ORD 기록
ord-03d93a8287534afdb6674f99f019dbb2
출처 데이터셋
uspto-grants-2014_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08633242B2

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