Trifluoroacetic acid → 5,7-dichloro-4-phenyl-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid

HRID 47370노트

반응식

HRID 47370 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([Cl:9])[CH:8]=1)[NH2:5].[CH2:10]([C:12](=O)[C:13]([O-:15])=[O:14])[CH3:11].C=C[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.FC(F)(F)C(O)=O.[OH-].[Na+]>C(#N)C.C(O)C>[Cl:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[C:4]2[C:3]=1[CH:11]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:10][CH:12]([C:13]([OH:15])=[O:14])[NH:5]2

참가 물질

8

반응물 5

HCID 6422Trifluoroacetic acidHCID 7501StyreneHCID 122813,5-DichloroanilineHCID 14798Sodium HydroxideHCID 35932772-Ketobutyrate

생성물 1

HCID 99231615,7-dichloro-4-phenyl-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid

시약·촉매·용매 2

HCID 702Ethanol용매HCID 6342Acetonitrile용매

실험 절차

Compound 15 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol styrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile. Subsequent saponification was carried out using 1.0 ml of sodium hydroxide solution (6N water) in 20.0 ml of ethanol.

출처 및 근거

ORD 기록
ord-d3e2222c3045443591698a2b7c600b99
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699877B2

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