Potassium Acetate → 6-Bromo-1H-indazole
반응식
F[B-](F)(F)F.[Br:6][C:7]1[CH:8]=[CH:9][C:10]([CH3:15])=[C:11]([N+:13]#[N:14])[CH:12]=1.C([O-])(=O)C.[K+]>C(Cl)(Cl)Cl.C1OCCOCCOCCOCCOCCOC1>[Br:6][C:7]1[CH:12]=[C:11]2[C:10]([CH:15]=[N:14][NH:13]2)=[CH:9][CH:8]=1참가 물질
5
실험 절차
5-Bromo-2-methylphenyldiazonium tetrafluoroborate (1.50 g) was added to a mixture of potassium acetate (1.0 g) and 18-crown-6 (70 mg) in chloroform (50 mL) at room temperature in portions and then the reaction was stirred for 2 h. The resulting mixture was filtered and washed with chloroform. The filtrate was concentrated, and the residue was dissolved in diethyl ether, which was then washed with water, brine, dried, and the solvent was removed to give the product 6-bromoindazole (0.9 g). The product was used in the next step without further purification.
후처리
- filtrationThe resulting mixture was filtered
- washwashed with chloroform
- concentrationThe filtrate was concentrated
- dissolutionthe residue was dissolved in diethyl ether
- washwhich was then washed with water, brine
- customdried
- customthe solvent was removed
출처 및 근거
- ORD 기록
- ord-66804a95cd6e4a919da44c3a3ec0d8a7
- 출처 데이터셋
- uspto-grants-2014_01
- 특허 번호
- US08637497B2
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