Sodium hydride → N-Methyl-N-(4,6-dimethyl-2-pyridyl)-1-[2-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)ethyl]benzimidazole-2-carboxamide

HRID 476896

반응식

HRID 476896 반응식
[CH3:1][N:2]([C:14]1[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([CH3:21])[N:15]=1)[C:3]([C:5]1[NH:6][C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[N:9]=1)=[O:4].[H-].[Na+].[CH3:24][O:25][C:26]1[CH:27]=[C:28]([CH:40]=[CH:41][C:42]=1[O:43][CH3:44])[C:29]([N:31]1[CH2:36][CH2:35][N:34]([CH2:37][CH2:38]Cl)[CH2:33][CH2:32]1)=[O:30].[Cl-].[NH4+]>CS(C)=O>[CH3:1][N:2]([C:14]1[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([CH3:21])[N:15]=1)[C:3]([C:5]1[N:6]([CH2:38][CH2:37][N:34]2[CH2:35][CH2:36][N:31]([C:29](=[O:30])[C:28]3[CH:40]=[CH:41][C:42]([O:43][CH3:44])=[C:26]([O:25][CH3:24])[CH:27]=3)[CH2:32][CH2:33]2)[C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[N:9]=1)=[O:4]

참가 물질

6

반응물 4

HCID 24758Sodium hydrideHCID 25517Ammonium ChlorideHCID 118091532-[4-(3,4-Dimethoxybenzoyl)-1-piperazinyl]ethyl chlorideHCID 14371319N-methyl-N-(4,6-dimethyl-2-pyridyl)benzimidazole-2-carboxamide

생성물 1

HCID 9809995N-Methyl-N-(4,6-dimethyl-2-pyridyl)-1-[2-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)ethyl]benzimidazole-2-carboxamide수율 79.2%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매2회

실험 절차

In an argon atmosphere, N-methyl-N-(4,6-dimethyl-2-pyridyl)benzimidazole-2-carboxamide (2.00 g) was dissolved in DMSO (15 ml), and 60% sodium hydride (0.33 g) was added and stirred at room temperature for 1 hr. A solution (7 ml) of 2-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]ethyl chloride (2.20 g) in DMSO was added dropwise and allowed to react overnight at room temperature under agitation. The reaction solution was added to an aqueous solution of ammonium chloride and extracted with chloroform, the chloroform layer was dried over Na2SO4, and the solvent was distilled off. Purification of the residue by column chromatography gave the title compound (3.10 g) as amorphous solid.

후처리

  1. customto react overnight at room temperature under agitation
  2. extractionextracted with chloroform
  3. dry with materialthe chloroform layer was dried over Na2SO4
  4. distillationthe solvent was distilled off
  5. customPurification of the residue by column chromatography

출처 및 근거

ORD 기록
ord-f6323285af62467588d63c16ce98f4cc
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04886803

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