Sodium hydride → N-(2-Pyridyl)-1-[2-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)ethyl]-5,6-dimethoxybenzimidazole-2-carboxamide

HRID 476898

반응식

HRID 476898 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]([C:10]1[NH:11][C:12]2[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21][CH3:22])=[CH:15][C:13]=2[N:14]=1)=[O:9].[H-].[Na+].[CH3:25][O:26][C:27]1[CH:28]=[C:29]([CH:41]=[CH:42][C:43]=1[O:44][CH3:45])[C:30]([N:32]1[CH2:37][CH2:36][N:35]([CH2:38][CH2:39]Cl)[CH2:34][CH2:33]1)=[O:31]>CS(C)=O>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]([C:10]1[N:11]([CH2:39][CH2:38][N:35]2[CH2:36][CH2:37][N:32]([C:30](=[O:31])[C:29]3[CH:41]=[CH:42][C:43]([O:44][CH3:45])=[C:27]([O:26][CH3:25])[CH:28]=3)[CH2:33][CH2:34]2)[C:12]2[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21][CH3:22])=[CH:15][C:13]=2[N:14]=1)=[O:9]

참가 물질

5

반응물 3

HCID 24758Sodium hydrideHCID 118091532-[4-(3,4-Dimethoxybenzoyl)-1-piperazinyl]ethyl chlorideHCID 19837066N-(2-pyridyl)-5,6-dimethoxybenzimidazole-2-carboxamide

생성물 1

HCID 14371293N-(2-Pyridyl)-1-[2-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)ethyl]-5,6-dimethoxybenzimidazole-2-carboxamide수율 44%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매2회

실험 절차

In an argon atmosphere, N-(2-pyridyl)-5,6-dimethoxybenzimidazole-2-carboxamide (0.85 g) was dissolved in DMSO (15 ml), and 60% sodium hydride (0.16 g) was added and stirred at room temperature for 1 hr. A solution (5 ml) of 2-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]ethyl chloride (1.25 g) in DMSO was added dropwise and allowed to react overnight at room temperature under agitation. After-treatment and purification in the same manner as described in Example 14 gave the title compound (0.72 g) as amorphous solid.

후처리

  1. customto react overnight at room temperature under agitation
  2. customAfter-treatment and purification in the same manner

출처 및 근거

ORD 기록
ord-2f436732b9d94704a5febb0c7011db82
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04886803

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