Hydrochloric Acid → 5-Methoxy-2-(pyridin-2-yl)aniline

HRID 477044노트

반응식

HRID 477044 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)=[C:5]([N+:15]([O-])=O)[CH:4]=1.Cl.[OH-].[Na+]>C(O)C>[NH2:15][C:5]1[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[CH:7][C:6]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 13924632HCID 13924632, 화합물

생성물 1

HCID 139246355-Methoxy-2-(pyridin-2-yl)aniline수율 68.2%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
100 °C

실험 절차

1.63 g of 2-(4-methoxy-2-nitrophenyl)pyridine was dissolved in 14 ml of ethanol, and 8 g of stannous chloride dihydrate and 5.7 ml of concentrated hydrochloric acid were added. The mixture was stirred at a bath temperature of 100° C. for 3 hours. After cooling, the reaction mixture was made alkaline with a 50% aqueous solution of sodium hydroxide and extracted with benzene. The solvent was evaporated. The resulting dark brown oil was subjected to silica gel column chromatography and the column was eluted with chloroform. As a yellow oil, 967 mg (yield 68.2%) of 2-(2-amino-4-methoxyphenyl)pyridine was obtained.

후처리

  1. temperatureAfter cooling
  2. extractionextracted with benzene
  3. customThe solvent was evaporated
  4. washthe column was eluted with chloroform

출처 및 근거

ORD 기록
ord-462921381ab24d8c83b51decc967a231
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04886822

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