Ammonia → 4-Thiazolemethanol, alpha-(bromomethyl)-2-(trifluoromethyl)-

HRID 477086노트

반응식

HRID 477086 반응식
[F:1][C:2]([F:13])([F:12])[C:3]1[S:4][CH:5]=[C:6]([C:8](=[O:11])[CH2:9][Br:10])[N:7]=1.[BH4-].[Na+].Cl.N>CO>[F:13][C:2]([F:1])([F:12])[C:3]1[S:4][CH:5]=[C:6]([CH:8]([OH:11])[CH2:9][Br:10])[N:7]=1

참가 물질

6

반응물 4

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 10978660HCID 10978660, 화합물

생성물 1

HCID 222204994-Thiazolemethanol, alpha-(bromomethyl)-2-(trifluoromethyl)-

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
10 °C

실험 절차

6 g (0.022 mol) of 2-Trifluoromethyl-4-bromoacetyl-thiazole are dissolved in 150 ml of methanol, and the solution is cooled to 10° C. and 0.63 g of sodium borohydride is added. After 15 minutes ice is added, and the mixture is acidified with hydrochloric acid, made alkaline with ammonia and extracted by shaking with methylene chloride. The organic phase is dried over sodium sulphate, filtered and concentrated. An oil is obtained and is reacted further as the crude product.

후처리

  1. additionAfter 15 minutes ice is added
  2. extractionextracted
  3. dry with materialThe organic phase is dried over sodium sulphate
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customAn oil is obtained

출처 및 근거

ORD 기록
ord-3a54d529ba3746babc35a3b2bbf99975
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04886814

반응 노트

불러오는 중…