Hydrochloric Acid → N-[2-(4-Carboxymethoxyphenyl)-1-methylethyl]-N-(2-hydroxyethyl)-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine

HRID 477136노트

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HRID 477136 반응식
[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([N:16]([CH2:29][CH2:30][OH:31])[CH2:17][CH:18]([OH:28])[C:19]2[N:20]=[C:21]([C:24]([F:27])([F:26])[F:25])[S:22][CH:23]=2)[CH3:15])=[CH:9][CH:8]=1)([O:3]C)=[O:2].[OH-].[Na+].Cl>CO>[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([N:16]([CH2:29][CH2:30][OH:31])[CH2:17][CH:18]([OH:28])[C:19]2[N:20]=[C:21]([C:24]([F:27])([F:25])[F:26])[S:22][CH:23]=2)[CH3:15])=[CH:9][CH:8]=1)([OH:3])=[O:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19974326HCID 19974326, 화합물

생성물 1

HCID 19974169N-[2-(4-Carboxymethoxyphenyl)-1-methylethyl]-N-(2-hydroxyethyl)-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Prepared by analogy to Example 16 by reaction of N-[2-(4-carbomethoxymethoxyphenyl)-1-methylethyl]-N-(2-hydroxyethyl)-2-hydroxy-2-(2-trifluoromethyl-thiazol-4yl)ethanamine in methanol with 1N sodium hydroxide solution. After the mixture has been neutralised with 1N hydrochloric acid it is evaporated to dryness, treated with 10 ml of ethanol, and the inorganic residues are removed by filtration. The ethanol phase is diluted with 60 ml of methylene chloride and again filtered. The mother liquor is evaporated to dryness, and the residue is triturated with ether and filtered off with suction.

후처리

  1. customis evaporated to dryness
  2. additiontreated with 10 ml of ethanol
  3. customthe inorganic residues are removed by filtration
  4. additionThe ethanol phase is diluted with 60 ml of methylene chloride
  5. filtrationagain filtered
  6. customThe mother liquor is evaporated to dryness
  7. customthe residue is triturated with ether
  8. filtrationfiltered off with suction

출처 및 근거

ORD 기록
ord-04f00b8034b44ecf8653b8ff5a556c31
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04886814

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