6-Methyluracil → HCID 178429729, 화합물

HRID 477553

반응식

HRID 477553 반응식
[CH3:1][C:2]1[NH:7][C:6](=[O:8])[NH:5][C:4](=O)[CH:3]=1.P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:11]>N1C=CC=CC=1>[OH:8][C:6]1[N:5]=[C:4]([SH:11])[CH:3]=[C:2]([CH3:1])[N:7]=1

참가 물질

4

반응물 2

HCID 122836-MethyluracilHCID 14817Phosphorus sulfide (P2S5)

생성물 1

HCID 178429729HCID 178429729, 화합물수율 136.5%

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
50 °C

실험 절차

6-Methyluracil (25.0 g) was suspended in 1 liter of distilled pyridine with stirring and heated at 50° C. into solution. Phosphorus pentasulfide (12.6 g) was then added, and the mixture was refluxed for 20 hours. The solution was concentrated under reduced pressure, then the residue was refluxed with 500 ml of ethanol for one hour. Insoluble materials were removed by filtration and the filtrate was concentrated under reduced pressure. The residue was recrystallized from ethanol, affording 5.5 g of the objective compound as colorless crystals.

후처리

  1. temperaturethe mixture was refluxed for 20 hours
  2. concentrationThe solution was concentrated under reduced pressure
  3. temperaturethe residue was refluxed with 500 ml of ethanol for one hour
  4. customInsoluble materials were removed by filtration
  5. concentrationthe filtrate was concentrated under reduced pressure
  6. customThe residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-8803435dd1da4637b5700b006de1fda9
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04888332

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