Benzyl Chloride → 5-(benzylsulfanyl)-4H-1,2,4-triazol-3-amine

HRID 477739노트

반응식

HRID 477739 반응식
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([SH:7])[N:3]=1.[OH-].[Na+].[CH2:10](Cl)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(O)C>[NH2:1][C:2]1[NH:6][N:5]=[C:4]([S:7][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:3]=1

참가 물질

5

반응물 3

HCID 7503Benzyl ChlorideHCID 14798Sodium HydroxideHCID 178509066HCID 178509066, 화합물

생성물 1

HCID 7372725-(benzylsulfanyl)-4H-1,2,4-triazol-3-amine수율 90.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

5-Amino-3-mercapto-1,2,4-triazole (40.36 g) in ethanol (450 ml) was treated at room temperature with solid sodium hydroxide (13.9 g), and benzyl chloride (44.3 g) was added dropwise. The solution was stirred overnight, filtered, and the residue was recrystallised from ethyl acetate and dried to give 64.97 g of desired product, mp 104° C.

후처리

  1. additionwas added dropwise
  2. filtrationfiltered
  3. customthe residue was recrystallised from ethyl acetate
  4. customdried

출처 및 근거

ORD 기록
ord-6fd3a55b65164c879b0f4f5236978b3e
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04889553

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