D-Tartaric acid → L-Malic Acid

HRID 4778

반응식

HRID 4778 반응식
[C@@H:1]([OH:10])([C:7]([OH:9])=[O:8])[C@H:2](O)[C:3]([OH:5])=[O:4]>CO>[C:7]([OH:9])(=[O:8])[C@H:1]([CH2:2][C:3]([OH:5])=[O:4])[OH:10]

참가 물질

3

반응물 1

HCID 439655D-Tartaric acid

생성물 1

HCID 222656L-Malic Acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

One of the intermediates, (S)-1-methyl-3-pyrrolidinol, was synthetized with retention of optical purity as shown in Chart IX starting with (S)-malic acid. The (S)-1-methyl-3-pyrrolidinol was shown to be dextrorotatory. As an alternative method of obtaining the resolved isomers of 1-methyl-3-pyrrolidinol, the racemic mixture was treated with (2S,3S)-tartaric acid in methanol. The resulting crystals, after one recrystallization, were converted to the base. This base was the dextrorotatory (S)-1-methyl-3-pyrrolidinol identical to that produced from (S)-malic acid.

후처리

  1. customThe resulting crystals, after one recrystallization

출처 및 근거

ORD 기록
ord-3facba9af3ca4dc89a1396be78296749
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04727152

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