Hydrochloric Acid → 2-Benzyl-3-dimethylaminosulphonyl-propionic acid
반응식
C([O:3][C:4](=[O:20])[CH:5]([CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:6][S:7]([N:10]([CH3:12])[CH3:11])(=[O:9])=[O:8])C.CO.[OH-].[Na+].Cl>O>[CH2:13]([CH:5]([CH2:6][S:7]([N:10]([CH3:12])[CH3:11])(=[O:9])=[O:8])[C:4]([OH:20])=[O:3])[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1참가 물질
6
실험 절차
A mixture of 299 mg of 2-benzyl-3-dimethylaminosulphonyl-propionic acid ethyl ester, 1 ml of methanol, 2 ml of water and 0.42 ml of 1H NaOH is stirred for 16 hours at room temperature, then neutralise with 0.42 ml of 1N HCl and extracted with ethyl acetate. The organic extracts are washed with water, dried, concentrated by evaporation and purified by chromatography on silica gel with eluant I. Rf (J)=0.48.
후처리
- extractionextracted with ethyl acetate
- washThe organic extracts are washed with water
- customdried
- concentrationconcentrated by evaporation
- custompurified by chromatography on silica gel with eluant I
출처 및 근거
- ORD 기록
- ord-94f9f106ed6b426fad81e5edc64cd89b
- 출처 데이터셋
- uspto-grants-1989_12
- 특허 번호
- US04889869
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