1-Methylpiperazine → Rac-cis-(3-fluoro-5-trifluoromethyl-phenyl)-[4-(4-methyl-piperazin-1-yl)-3-phenyl-piperidin-1-yl]-methanone

HRID 478450

반응식

HRID 478450 반응식
C([N:8]1[CH2:13][CH2:12][C:11](=O)[CH:10]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:9]1)C1C=CC=CC=1.[CH3:21][N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1.[F:28][C:29]1[CH:30]=[C:31]([CH:35]=[C:36]([C:38]([F:41])([F:40])[F:39])[CH:37]=1)[C:32](Cl)=[O:33]>>[F:28][C:29]1[CH:30]=[C:31]([C:32]([N:8]2[CH2:13][CH2:12][C@H:11]([N:25]3[CH2:26][CH2:27][N:22]([CH3:21])[CH2:23][CH2:24]3)[C@H:10]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH2:9]2)=[O:33])[CH:35]=[C:36]([C:38]([F:41])([F:40])[F:39])[CH:37]=1

참가 물질

4

반응물 3

HCID 531671-MethylpiperazineHCID 5193643-Fluoro-5-(trifluoromethyl)benzoyl chlorideHCID 118179561-Benzyl-3-phenylpiperidin-4-one

생성물 1

HCID 131724196Rac-cis-(3-fluoro-5-trifluoromethyl-phenyl)-[4-(4-methyl-piperazin-1-yl)-3-phenyl-piperidin-1-yl]-methanone

실험 절차

The title compound, MS: m/e=450.5 (M+H+), was prepared in accordance with the general method of example 26 from 1-benzyl-3-phenyl-piperidin-4-one, N-methyl-piperazine and 3-fluoro-5-trifluoromethyl-benzoyl chloride.

출처 및 근거

ORD 기록
ord-dbc47a6288dd4a21a98a2f2659bd951e
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06642226B2

연결된 노트

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