Hydrochloric Acid → Methyl 3-(2-aminoethyl)benzoate

HRID 480331노트

반응식

HRID 480331 반응식
[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][C:11]#[N:12])[CH:5]=1.Cl>CCO.O=[Pt]=O>[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][CH2:11][NH2:12])[CH:5]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 10821136Methyl 3-(cyanomethyl)benzoate

생성물 1

HCID 10511548Methyl 3-(2-aminoethyl)benzoate수율 84.8%

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 702Ethanol용매

실험 절차

A solution of 3-cyanomethyl-benzoic acid methyl ester (1.36 g) in EtOH (25 mL) was saturated with HCl (g) and PtO2 (200 mg) was added. The reaction was hydrogenated on a Parr shaker at 50 psi for 2.5 h. The catalyst was removed via filtration through Celite and the solvent was removed in vacuo. The resulting solid was stirred in Et2O and the mixture was filtered to yield the title compound as a white solid (1.18 g). MS 180 (M+1).

후처리

  1. additionwas added
  2. customThe catalyst was removed via filtration through Celite
  3. customthe solvent was removed in vacuo
  4. filtrationthe mixture was filtered

출처 및 근거

ORD 기록
ord-5b0d8eada1d5469d983210761aa9d363
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06649657B2

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