Sodium Hydroxide → 6-Bromo-2-hydroxynaphthalene-1-carboxylic acid

HRID 480450

반응식

HRID 480450 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([CH:12]=[O:13])=[C:7]([OH:14])[CH:6]=[CH:5]2.[O-:15]Cl=O.[Na+].[OH-].[Na+]>CS(C)=O.O>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([C:12]([OH:15])=[O:13])=[C:7]([OH:14])[CH:6]=[CH:5]2

참가 물질

6

반응물 3

HCID 14798Sodium HydroxideHCID 7354576-Bromo-2-hydroxy-1-naphthaldehydeHCID 23668197Sodium Chlorite2회

생성물 1

HCID 187690886-Bromo-2-hydroxynaphthalene-1-carboxylic acid수율 87.4%

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 962Water용매2회

실험 절차

To a ice-cooled mixture of 6-Bromo-2-hydroxy-1-naphthaldehyde (24.0 g) and aqueous NaH2PO4 solution (3.2 g in 30 mL of water) in DMSO (160 mL) was added dropwise a solution of NaClO2 (80%; 15.1 g) in water (150 mL) over 1 h. After being stirred for 5 h at room temperature, a solution of NaClO2 (80%; 2.16 g) in water (20 mL) was added, and the reaction mixture was further stirred for 2 h at room temperature. The mixture was alkalized with 1N-NaOH, and the precipitate was filtered off. The filtrate was washed with AcOEt and iPr2O, and then the aqueous phase was acidified with conc. HCl. The precipitate was filtered, washed with water, and dried in vacuo to give the title compound (22.3 g) as a brown powder.

후처리

  1. stirringthe reaction mixture was further stirred for 2 h at room temperature
  2. filtrationthe precipitate was filtered off
  3. washThe filtrate was washed with AcOEt and iPr2O
  4. filtrationThe precipitate was filtered
  5. washwashed with water
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-73b91b7fca7a45499716b10d2f9d370b
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06649643B1

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