Azobisisobutyronitrile → Methyl 2-(1-bromoethyl)benzoate

HRID 480554

반응식

HRID 480554 반응식
[Br:1]N1C(=O)CCC1=O.N(C(C)(C)C#N)=NC(C)(C)C#N.[CH2:21]([C:23]1[CH:32]=[CH:31][CH:30]=[CH:29][C:24]=1[C:25]([O:27][CH3:28])=[O:26])[CH3:22]>C(Cl)(Cl)(Cl)Cl>[Br:1][CH:21]([C:23]1[CH:32]=[CH:31][CH:30]=[CH:29][C:24]=1[C:25]([O:27][CH3:28])=[O:26])[CH3:22]

참가 물질

5

반응물 3

HCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 583295Methyl 2-ethylbenzoate

생성물 1

HCID 15870654Methyl 2-(1-bromoethyl)benzoate수율 82.1%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

반응 조건

온도
80 °C

실험 절차

N-Bromosuccinimide (10.7 g) and azodiisobutyronitrile (catalytic) were added to a solution of methyl 2-ethylbenzoate (10 g) in carbon tetrachloride (50 ml), and the resulting mixture was heated at 80° C. for 6 hours under reflux. After cooling, the reaction mixture was filtered and the filtrate was concentrated to give methyl 2-(1-bromoethyl)benzoate (12 g), almost pure by GC and NMR, as a yellow oil.

후처리

  1. temperatureunder reflux
  2. temperatureAfter cooling
  3. filtrationthe reaction mixture was filtered
  4. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-03fa7aaa45b147b7af762b66e71acd3f
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06653258B1

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