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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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1,6-Cleve's acid → 5-({3-Nitro-5-[N-(6-sulfonaphthyl)carbamoyl]phenyl}carbonylamino)-naphthalene-2-sulfonic Acid

HRID 480669
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HRID 480669 반응식
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([S:12]([OH:15])(=[O:14])=[O:13])=[CH:7]2.[N+:16]([C:19]1[CH:20]=[C:21]([C:28](Cl)=[O:29])[CH:22]=[C:23]([C:25](Cl)=[O:26])[CH:24]=1)([O-:18])=[O:17]>N1C=CC=CC=1.O1CCOCC1.C(Cl)(Cl)Cl>[N+:16]([C:19]1[CH:20]=[C:21]([C:28]([NH:1][C:2]2[CH:11]=[CH:10][CH:9]=[C:8]3[C:3]=2[CH:4]=[CH:5][C:6]([S:12]([OH:15])(=[O:13])=[O:14])=[CH:7]3)=[O:29])[CH:22]=[C:23]([C:25](=[O:26])[NH:1][C:2]2[C:3]3[C:8](=[CH:7][C:6]([S:12]([OH:15])(=[O:13])=[O:14])=[CH:5][CH:4]=3)[CH:9]=[CH:10][CH:11]=2)[CH:24]=1)([O-:18])=[O:17]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 2

HCID 84081,6-Cleve's acidHCID 834515-Nitroisophthaloyl chloride

생성물 1

HCID 120946535-({3-Nitro-5-[N-(6-sulfonaphthyl)carbamoyl]phenyl}carbonylamino)-naphthalene-2-sulfonic Acid

시약·촉매·용매 3

HCID 1049Pyridine용매HCID 6212Chloroform용매HCID 31275
1,4-Dioxane
용매

실험 절차

22.33 g (0.10 mol) of 5-amino-2-naphthalenesulfonic acid was suspended in 150 mL of pyridine and added to the above di-acid chloride in 50 mL (50:50) of dioxane and CHCl3 under vigorous stirring for 1-2 hrs. The crude product was precipitated with dioxane. The oily product was collected on a Büchner funnel. The brown colored oily product was dissolved in 500 mL water, then allowed to precipitate out over 30 min. The solid material was collected using filtration. It yielded 16.2 g.

후처리

  1. customThe crude product was precipitated with dioxane
  2. customThe oily product was collected on a Büchner funnel
  3. dissolutionThe brown colored oily product was dissolved in 500 mL water
  4. customto precipitate out over 30 min
  5. customThe solid material was collected
  6. filtrationfiltration
  7. customIt yielded 16.2 g

출처 및 근거

ORD 기록
ord-5e3368348bc7428f8858fabd35c3d318
출처 데이터셋
uspto-grants-2003_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06653321B1

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