Hydrochloric Acid → 3-[(Tert-butyldimethylsilyl)oxy]propan-1-ol

HRID 48086

반응식

HRID 48086 반응식
[CH2:1]([OH:5])[CH2:2][CH2:3][OH:4].[C:6]([Si:10]([CH3:13])([CH3:12])Cl)([CH3:9])([CH3:8])[CH3:7].N1C=CN=C1.Cl>CN(C=O)C>[O:4]([CH2:3][CH2:2][CH2:1][OH:5])[Si:10]([C:6]([CH3:9])([CH3:8])[CH3:7])([CH3:13])[CH3:12]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 795ImidazoleHCID 104421,3-PropanediolHCID 28928tert-Butyldimethylsilyl chloride

생성물 1

HCID 40777913-[(Tert-butyldimethylsilyl)oxy]propan-1-ol

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 1,3-propanediol (10 mmol), tert-butyldimethylchlorosilane (11 mmol), and imidazole (22 mmol) dissolved in 5 mL of DMF was stirred at room temperature for 16 hours. The mixture was poured into 0.1 M HCl (100 mL) and extracted with ether (3×100 mL). The organic phases were washed with brine (100 mL), dried over anhydrous MgSO4, and concentrated in vacuo. The mixture was purified by flash chromatography to give the product as a colorless oil.

후처리

  1. extractionextracted with ether (3×100 mL)
  2. washThe organic phases were washed with brine (100 mL)
  3. dry with materialdried over anhydrous MgSO4
  4. concentrationconcentrated in vacuo
  5. customThe mixture was purified by flash chromatography

출처 및 근거

ORD 기록
ord-3c0d0e4f28e3497f83930e61cad01c92
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06702705B1

연결된 노트

불러오는 중…