Azobisisobutyronitrile → 1-(5-Bromomethylpyridin-2-yl)cyclopentanecarboxlic acid ethyl ester

HRID 481402노트

반응식

HRID 481402 반응식
[CH2:1]([O:3][C:4]([C:6]1([C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][N:12]=2)[CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:5])[CH3:2].C1C(=O)N([Br:25])C(=O)C1.N(C(C)(C)C#N)=NC(C)(C)C#N>C(Cl)(Cl)(Cl)Cl>[CH2:1]([O:3][C:4]([C:6]1([C:11]2[CH:16]=[CH:15][C:14]([CH2:17][Br:25])=[CH:13][N:12]=2)[CH2:7][CH2:8][CH2:9][CH2:10]1)=[O:5])[CH3:2]

참가 물질

5

반응물 3

HCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 572450121-(5-Methylpyridin-2-yl)cyclopentane carboxylic acid ethyl ester2회

생성물 1

HCID 701035861-(5-Bromomethylpyridin-2-yl)cyclopentanecarboxlic acid ethyl ester

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

반응 조건

온도
0 °C

실험 절차

A mixture containing the product of Step 2, above (44) (1 equiv.), n-bromosuccinimide (1.1 equiv.), CCl4 and a catalytic amount of azobisisobutyronitrile was heated at reflux for 4 hours, cooled to 0° C. and filtered through celite. The residue was washed well with CCl4 and the filtrate was concentrated and chromatographed on silica gel to yield the title compound (45).

후처리

  1. temperatureat reflux for 4 hours
  2. filtrationfiltered through celite
  3. washThe residue was washed well with CCl4
  4. concentrationthe filtrate was concentrated
  5. customchromatographed on silica gel

출처 및 근거

ORD 기록
ord-7289d1e66d054edab6bb6e540f7037b8
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05789415

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