Hydroxyphenylacetic acid → Benzeneacetic acid, 4-hydroxy-, methyl ester

HRID 48146

반응식

HRID 48146 반응식
Cl.[OH:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1.[CH3:13]O>>[CH3:13][O:11][C:10](=[O:12])[CH2:9][C:6]1[CH:5]=[CH:4][C:3]([OH:2])=[CH:8][CH:7]=1

참가 물질

4

반응물 3

HCID 127Hydroxyphenylacetic acidHCID 313Hydrochloric AcidHCID 887Methanol

생성물 1

HCID 518900Benzeneacetic acid, 4-hydroxy-, methyl ester

실험 절차

Hydrogen chloride was bubbled through a solution of (4-hydroxyphenyl) acetic acid (25 g, 0.16 mole) in methanol (100 ml) at room temperature. An exotherm resulted in the solution refluxing for about 10 minutes. The mixture was allowed to cool to room temperature and the solvent was evaporated in vacuo to afford methyl(4-hydroxyphenyl)acetate as a yellow oil (27.5 g) which crystallised on seeding, m.p. 46-52° C.

후처리

  1. customAn exotherm resulted in the solution
  2. temperaturerefluxing for about 10 minutes
  3. customthe solvent was evaporated in vacuo

출처 및 근거

ORD 기록
ord-123330c67b6b4ba3a55b2d817c1c4a56
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06703347B2

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