Hydroxyphenylacetic acid → Benzeneacetic acid, 4-hydroxy-, methyl ester

반응식

Cl.[OH:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1.[CH3:13]O>>[CH3:13][O:11][C:10](=[O:12])[CH2:9][C:6]1[CH:5]=[CH:4][C:3]([OH:2])=[CH:8][CH:7]=1

참가 물질

반응물 3

HCID 127Hydroxyphenylacetic acid

HCID 313Hydrochloric Acid

HCID 887Methanol

생성물 1

HCID 518900Benzeneacetic acid, 4-hydroxy-, methyl ester

실험 절차

Hydrogen chloride was bubbled through a solution of (4-hydroxyphenyl) acetic acid (25 g, 0.16 mole) in methanol (100 ml) at room temperature. An exotherm resulted in the solution refluxing for about 10 minutes. The mixture was allowed to cool to room temperature and the solvent was evaporated in vacuo to afford methyl(4-hydroxyphenyl)acetate as a yellow oil (27.5 g) which crystallised on seeding, m.p. 46-52° C.