Carbon tetrabromide → 4-(1,1-Dimethyl-3,3-dibromo-2-propenyl)anisole

HRID 481523

반응식

HRID 481523 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([CH3:13])([CH3:12])[CH:10]=O)=[CH:5][CH:4]=1.[C:14](Br)(Br)([Br:16])[Br:15].C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>C(Cl)Cl>[CH3:12][C:9]([C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)([CH3:13])[CH:10]=[C:14]([Br:16])[Br:15]

참가 물질

5

반응물 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 111376892-(4-Methoxyphenyl)-2-methylpropanal

생성물 1

HCID 190664224-(1,1-Dimethyl-3,3-dibromo-2-propenyl)anisole수율 45%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of Compound 45 (3.0 g, 17 mmol) and CBr4 (11 g, 34 mmol) in CH2Cl2 (100 ml) was added PPh3 (18 g, 67 mmol) at r.t., and stirred for 1.5 h. The mixture was quenched by the addition of H2O, and extracted with CH2Cl2. The combined organic layers were washed with brine, dried over MgSO4, filtered, and concentrated. This was purified by SiO2 chromatography to give Compound 53 (2.5 g, 45%) as a colorless oil.

후처리

  1. customThe mixture was quenched by the addition of H2O
  2. extractionextracted with CH2Cl2
  3. washThe combined organic layers were washed with brine
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customThis was purified by SiO2 chromatography

출처 및 근거

ORD 기록
ord-7fb77abeec4e4e33acaabbbc6f9447a3
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05789423

연결된 노트

불러오는 중…