Xanthine → 1,3-Dimethyl-7-(6-hydroxyhexyl)-xanthine

HRID 482882

반응식

HRID 482882 반응식
[CH3:1][N:2]1[C:11](=[O:12])[C:10]2[N:9]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]Br)[CH:8]=[N:7][C:6]=2[N:5]([CH3:20])[C:3]1=[O:4].C([O-])(=[O:23])C.[K+].N1C(=O)C2NC=NC=2NC1=O.[I-].[K+]>C(OC(=O)C)(=O)C.C(O)(=O)C>[CH3:1][N:2]1[C:11](=[O:12])[C:10]2[N:9]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][OH:23])[CH:8]=[N:7][C:6]=2[N:5]([CH3:20])[C:3]1=[O:4]

참가 물질

7

반응물 4

HCID 1188XanthineHCID 4875Potassium IodideHCID 517044Potassium AcetateHCID 202440737-(6-Bromohexyl)-1,3-dimethylxanthine

생성물 1

HCID 108027041,3-Dimethyl-7-(6-hydroxyhexyl)-xanthine

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 7918Acetic Anhydride용매

실험 절차

1,3-dimethyl-7-(6-bromohexyl)-xanthine is refluxed overnight with a sixfold molar excess of potassium acetate with the addition of catalytic quantities, such as 2 mol percent, referred to the xanthine, of potassium iodide in a mixture of 5 ml of acetic anhydride and 200 ml of glacial acetic acid. The solvent is evaporated in vacuo. The residue is dissolved in water and the pH of the solution is adjusted to a value of 7 with 4N sodium hydroxide. The solution is then extracted with chloroform. The isolated 1,3-dimethyl-7-(acetoxyhexyl)-xanthine is subsequently hydrolysed to the corresponding hydroxyalkyl compound by boiling with 5% sulfuric acid.

후처리

  1. additionwith the addition of catalytic quantities
  2. customThe solvent is evaporated in vacuo
  3. dissolutionThe residue is dissolved in water
  4. extractionThe solution is then extracted with chloroform

출처 및 근거

ORD 기록
ord-e571a2eb32c64f79b711437d06908a8a
출처 데이터셋
uspto-grants-1986_03
특허 번호
US04576947

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