Ethanol → HCID 178527812, 화합물

HRID 48295노트

반응식

HRID 48295 반응식
CC(C)CN[C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[CH:7][C:6]=1[NH2:15].[C:17](=[S:19])=[S:18].C(O)C>[OH-].[Na+]>[S:18]1[C:5]2[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[CH:7][C:6]=2[N:15]=[C:17]1[SH:19]

참가 물질

5

반응물 3

HCID 702EthanolHCID 6348Carbon DisulfideHCID 11298872N4-(2-methylpropyl)quinoline-3,4-diamine

생성물 1

HCID 178527812HCID 178527812, 화합물

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

N4-(2-methylpropyl)quinoline-3,4-diamine (5.4 g, 25 mmol) was combined with carbon disulfide (9 mL, 150 mmol) and ethanol (55 mL) and then heated at reflux on a steam bath for 2 hours. The resulting precipitate was isolated by filtration, washed with ethanol and then air dried to provide 4.4 g of crude product. A portion (1 g) was dissolved in hot dilute sodium hydroxide and then reprecipitated with acetic acid. The precipitate was isolated by filtration while still hot, washed with hexane and then air dried to provide thiazolo[4,5-c]quinoline-2-thiol as a solid, m.p. 282-284° C. Analysis: Calculated for C10H6N2S2: %C, 55.02; %H, 2.77; %N, 12.83: Found: %C, 54.96; %H, 2.69; %N, 12.74.

후처리

  1. temperatureheated
  2. temperatureat reflux on a steam bath for 2 hours
  3. customThe resulting precipitate was isolated by filtration
  4. washwashed with ethanol
  5. customair dried
  6. customto provide 4.4 g of crude product
  7. customreprecipitated with acetic acid
  8. customThe precipitate was isolated by filtration while still hot,
  9. washwashed with hexane
  10. customair dried

출처 및 근거

ORD 기록
ord-bf8a366e53444547b50e58f7ba7ad65d
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06703402B2

반응 노트

불러오는 중…