Chloroacetamide → Ethyl 2,5-dioxo-3-pyrrolidinecarboxylate

HRID 483104

반응식

HRID 483104 반응식
[C:1]([O:9]CC)(=O)[CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[H-].[Na+].Cl[CH2:15][C:16]([NH2:18])=[O:17]>CN(C)C=O>[CH2:6]([O:5][C:3]([CH:2]1[CH2:15][C:16](=[O:17])[NH:18][C:1]1=[O:9])=[O:4])[CH3:7]

참가 물질

5

반응물 3

HCID 6580ChloroacetamideHCID 7761Diethyl MalonateHCID 24758Sodium hydride

생성물 1

HCID 23635561Ethyl 2,5-dioxo-3-pyrrolidinecarboxylate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of diethyl malonate (6.1 ml) in N,N-dimethylformamide (30 ml) are added 60% sodium hydride (1.6 g) at 0° C. and, after 8 minutes, chloroacetamide (1.87 g). After stirring at room temperature for 3.5 hours, the mixture in neutralized with acetic acid and extracted with ethyl acetate. The extract is washed with water and concentrated to give 2,5-dioxopyrrolidine-3-carboxylic acid ethyl ester. Oil.

후처리

  1. extractionthe mixture in neutralized with acetic acid and extracted with ethyl acetate
  2. washThe extract is washed with water
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a315d93cc0df448580a90e1858c3b76d
출처 데이터셋
uspto-grants-1986_03
특허 번호
US04578378

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