Water → 1-Methyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde

HRID 483172

반응식

HRID 483172 반응식
[CH:1]([C:3]1[C:4](=[O:13])[NH:5][C:6]2[C:11]([CH:12]=1)=[CH:10][CH:9]=[CH:8][CH:7]=2)=[O:2].[H-].[Na+].[CH3:16]I.O>O1CCCC1>[CH3:16][N:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH:12]=[C:3]([CH:1]=[O:2])[C:4]1=[O:13]

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 5893342-Hydroxyquinoline-3-carbaldehyde

생성물 1

HCID 49146281-Methyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

2.7 Grams of 3-formylcarbostyril was dissolved in 150 ml of tetrahydrofuran, then 0.8 g of oil 50%-sodium hydride was added thereto at a room temperature with stirring. Next, 4.5 g of methyl iodide was added dropwise at a room temperature for 3 hours. The reaction mixture was concentrated under a reduced pussure, the residue thus obtained was poured into water and the crystals precipitated were collected by filtration. Recrystallized from ethanol to obtain 1.7 g of 1-methyl-3-formylcarbostyril in the form of yellow-brownish needle-like crystals.

후처리

  1. concentrationThe reaction mixture was concentrated under a reduced pussure
  2. customthe residue thus obtained
  3. customthe crystals precipitated
  4. filtrationwere collected by filtration
  5. customRecrystallized from ethanol

출처 및 근거

ORD 기록
ord-15e919ed724a4f5188bf968090ad1273
출처 데이터셋
uspto-grants-1986_03
특허 번호
US04578381

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