Hydrochloric Acid → Tetrahydropyranyl methacrylate

HRID 483329

반응식

HRID 483329 반응식
[C:1]([OH:6])(=[O:5])[C:2]([CH3:4])=[CH2:3].[O:7]1[CH:12]=[CH:11][CH2:10][CH2:9][CH2:8]1.Cl.C(=O)(O)[O-].[Na+]>[N+](C1C=C([N+]([O-])=O)C=CC=1C)([O-])=O.Cl>[C:1]([O:6][CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12][O:7]1)(=[O:5])[C:2]([CH3:4])=[CH2:3]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 4093Methacrylic AcidHCID 80803,4-dihydro-2H-pyranHCID 516892Sodium Bicarbonate

생성물 1

HCID 11041138Tetrahydropyranyl methacrylate수율 91%

시약·촉매·용매 2

HCID 313Hydrochloric Acid촉매HCID 84612,4-Dinitrotoluene촉매

반응 조건

온도
50 °C

실험 절차

to a solution of 25.8 g (0.3 mol) methacrylic acid and 1.8 g (0.011 mol) 2,4-dinitrotoluene in 25.2 g (0.3 mol) dihydropyran was added 0.05 ml (0.0015 mol) concentrated hydrochloric acid. The reaction mixture was allowed to stir at 50° C. for 25 hr. The hydrochloric acid was neutralized with solid sodium bicarbonate and the mixture was filtered. The filtrate was distilled to give 46.5 g (0.273 mol, 91% yield) tetrahydropyran-2-yl methacrylate, bp 50° C. at 0.15 torr.

후처리

  1. filtrationthe mixture was filtered
  2. distillationThe filtrate was distilled

출처 및 근거

ORD 기록
ord-a4b22e8e27be4e7fb3eadcb1543bfa82
출처 데이터셋
uspto-grants-1993_07
특허 번호
US05225316

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