3,4-dihydro-2H-pyran → 2H-Pyran, 2-(4-chlorobutoxy)tetrahydro-

HRID 483466

반응식

HRID 483466 반응식
[O:1]1[CH:6]=[CH:5][CH2:4][CH2:3][CH2:2]1.[Cl:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12]>Cl>[Cl:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][CH:6]1[CH2:5][CH2:4][CH2:3][CH2:2][O:1]1

참가 물질

4

반응물 2

HCID 80803,4-dihydro-2H-pyranHCID 135694-Chloro-1-butanol

생성물 1

HCID 1704882H-Pyran, 2-(4-chlorobutoxy)tetrahydro-수율 89.9%

시약·촉매·용매 1

HCID 313Hydrochloric Acid촉매

실험 절차

Dihydropyran (15.5 g) was added dropwise to a mixture of 4-chlorobutanol (20 g) and hydrochloric acid (18M, 1 drop) at RT. The mixture was stirred for 30 min and washed with H2O (100 ml), aqueous NaHCO3 (1M, 50ml) and BR (50 ml). The dried liquid was heated under reduced pressure to leave the title compound as a colourless liquid (31.9 g). T.l.c. [L] Rf 0.5.

후처리

  1. washwashed with H2O (100 ml), aqueous NaHCO3 (1M, 50ml) and BR (50 ml)
  2. temperatureThe dried liquid was heated under reduced pressure

출처 및 근거

ORD 기록
ord-2f1f6bb3aa0943b0855f794fab0230c3
출처 데이터셋
uspto-grants-1993_07
특허 번호
US05225445

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