Hydrochloric Acid → 4-(Hexadecyloxy)phenol

HRID 483576노트

반응식

HRID 483576 반응식
[H-].[Na+].[C:3]1([CH:10]=[CH:9][C:7]([OH:8])=[CH:6][CH:5]=1)[OH:4].I[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27].Cl>CN(C)C=O.O1CCCC1>[CH2:27]([O:4][C:3]1[CH:10]=[CH:9][C:7]([OH:8])=[CH:6][CH:5]=1)[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH3:12]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 785HydroquinoneHCID 110071-IodohexadecaneHCID 24758Sodium hydride

생성물 1

HCID 43779374-(Hexadecyloxy)phenol

시약·촉매·용매 2

HCID 6228Dimethylformamide용매2회HCID 8028Tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

To a suspension of 28.99 g of 60% sodium hydride in 350 ml of N,N-dimethylformamide, cooled to 0° C. and under argon is added 60 g of hydroquinone in 450 ml of N,N-dimethylformamide with stirring over 40 minutes. After an additional 30 minutes, 450 ml of tetrahydrofuran is added followed by 192 g of 1-iodohexadecane over one hour. The mixture is stirred at room temperature for 3 hours. The reaction mixture is poured into dilute hydrochloric acid and extracted with chloroform. The organic layer is washed with water, dried and evaporated to give the desired product as an oil.

후처리

  1. waitAfter an additional 30 minutes
  2. stirringThe mixture is stirred at room temperature for 3 hours
  3. extractionextracted with chloroform
  4. washThe organic layer is washed with water
  5. customdried
  6. customevaporated

출처 및 근거

ORD 기록
ord-faa45f0b625446559bd33c5c5b4dbe3c
출처 데이터셋
uspto-grants-1993_07
특허 번호
US05225425

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