4-Methylmorpholine → Boc-gly-pro-OH

HRID 483642

반응식

HRID 483642 반응식
CN1CCOCC1.[NH:8]1[CH2:15][CH2:14][CH2:13][C@H:9]1[C:10]([OH:12])=[O:11].[NH:16]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:17][C:18](ON1C(=O)CCC1=O)=[O:19]>CN(C=O)C>[NH:16]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:17][C:18]([N:8]1[CH2:15][CH2:14][CH2:13][C@H:9]1[C:10]([OH:12])=[O:11])=[O:19]

참가 물질

5

반응물 3

HCID 79724-Methylmorpholine2회HCID 76926N-(tert-Butyloxycarbonyl)glycine N-hydroxysuccinimide esterHCID 145742L-Proline

생성물 1

HCID 11673468Boc-gly-pro-OH

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

1.4 ml (11 mmol) of N-methylmorpholine are added to 1.15 g (10 mmol) of proline in 50 ml of DMF. The mixture is cooled with an ice bath, 3.06 g (10 mmol) of Boc-Gly-OSu are then added and the pH is adjusted to between 6 and 7 throughout the reaction (14 h) by successive additions of small amounts of N-methylmorpholine (this substance is used as a proton acceptor). The DMF is evaporated off and the evaporation residue is taken up with AcOEt; after precipitation in petroleum ether and then filtration, the expected product is collected.

후처리

  1. temperatureThe mixture is cooled with an ice bath
  2. customThe DMF is evaporated off
  3. customafter precipitation in petroleum ether
  4. filtrationfiltration
  5. customthe expected product is collected

출처 및 근거

ORD 기록
ord-46a95c7b3d8442cca33271779bfafde1
출처 데이터셋
uspto-grants-1993_07
특허 번호
US05225532

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