2-Chloro-4-nitropyridine 1-oxide → Pyridine, 2-chloro-4-methoxy-, 1-oxide

HRID 483758

반응식

HRID 483758 반응식
[Na].[CH3:2][O-:3].[Na+].[Cl:5][C:6]1[CH:11]=[C:10]([N+]([O-])=O)[CH:9]=[CH:8][N+:7]=1[O-:15]>CO>[Cl:5][C:6]1[CH:11]=[C:10]([O:3][CH3:2])[CH:9]=[CH:8][N+:7]=1[O-:15]

참가 물질

5

반응물 3

HCID 844332-Chloro-4-nitropyridine 1-oxideHCID 5360545SodiumHCID 10942334Sodium Methoxide

생성물 1

HCID 15593755Pyridine, 2-chloro-4-methoxy-, 1-oxide

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

Sodium (0.46 g) is dissolved in absolute methanol (50 ml) and the resultant solution of sodium methoxide is added to a solution of 2-chloro-4-nitropyridine-1-oxide (3.5 g, prepared as described in Example 1) in methanol (10 ml). The reaction mixture is allowed to stand at room temperature for 50 hours and is then subjected to rotary evaporation to give 2-chloro-4-methoxypyridine-1-oxide.

후처리

  1. customis then subjected to rotary evaporation

출처 및 근거

ORD 기록
ord-20eeab3c45f14020a6979e4c216e0572
출처 데이터셋
uspto-grants-1993_07
특허 번호
USRE034313

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