Phosphorus tribromide → (5-Bromopentyl)benzene

HRID 484337

반응식

HRID 484337 반응식
P(Br)(Br)[Br:2].[C:5]1([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]O)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>C(Cl)(Cl)Cl>[C:5]1([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][Br:2])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromide2회HCID 615235-Phenyl-1-pentanol

생성물 1

HCID 285561(5-Bromopentyl)benzene

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A 1.8 g (6.7 mmol) amount of phosphorus tribromide was added to a chloroform solution (20 ml) of 3.3 g (20 mmol) of 5-phenyl-1-pentanol and the resulting solution was heated at reflux for 4 hours. When the reaction was traced by TLC, the starting materials were found to still remain in the reaction mixture, and so 0.2 g of phosphorus tribromide was further added and heated at reflux. Afterwards, the reaction solution was washed with water and dried with anhydrous magnesium sulfate, and then the solvent was evaporated under reduced pressure. Thus, 4.30 g of a crude 5-phenylpentyl bromide was obtained.

후처리

  1. temperaturethe resulting solution was heated
  2. temperatureat reflux for 4 hours
  3. additionwas further added
  4. temperatureheated
  5. temperatureat reflux
  6. washAfterwards, the reaction solution was washed with water
  7. dry with materialdried with anhydrous magnesium sulfate
  8. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-37c2e7860e4e4a2284712f3d40aed8d0
출처 데이터셋
uspto-grants-1993_07
특허 번호
US05231105

연결된 노트

불러오는 중…