Formamide → HCID 178518030, 화합물

HRID 48447

반응식

HRID 48447 반응식
C[O:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][C:9]=1[NH2:10])=O.[CH:11]([NH2:13])=O>O>[OH:2][C:3]1[C:5]2[S:6][CH:7]=[CH:8][C:9]=2[N:10]=[CH:11][N:13]=1

참가 물질

4

반응물 2

HCID 713FormamideHCID 89652Methyl 3-amino-2-thiophenecarboxylate

생성물 1

HCID 178518030HCID 178518030, 화합물

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
200 °C

실험 절차

3-aminothiophene-2-carboxylic acid methylester (1.6 g, 10 mmol) was added to formamide (3.4 ml), and the mixture was stirred at 200° C. for 2 hours. The reaction mixture was returned to room temperature, and water was added thereto, which was extracted with chloroform. The solid obtained by distilling off the solvent under reduced pressure was washed with ethyl acetate to obtain 4-hydroxythieno[3,2-d]pyrimidine (60 mg, 0.39 mmol).

후처리

  1. customwas returned to room temperature
  2. extractionwhich was extracted with chloroform
  3. customThe solid obtained
  4. distillationby distilling off the solvent under reduced pressure
  5. washwas washed with ethyl acetate

출처 및 근거

ORD 기록
ord-acd8ccb1d4e34ab0a44c61593a48bc0e
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06703421B1

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