Hydrogen Bromide → 1-Methyl-3-bromopropyldimethylamine hydrobromide

HRID 484837노트

반응식

HRID 484837 반응식
[CH3:1][CH:2]([N:12]([CH3:14])[CH3:13])[CH2:3][CH2:4]OC1C=CC=CC=1.[BrH:15]>C(Cl)(Cl)Cl>[BrH:15].[CH3:1][CH:2]([N:12]([CH3:14])[CH3:13])[CH2:3][CH2:4][Br:15]

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 201358801-Methyl-3-phenoxypropyldimethylamine

생성물 1

HCID 201357911-Methyl-3-bromopropyldimethylamine hydrobromide수율 79%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

5 g of the 1-methyl-3-phenoxypropyldimethylamine thus obtained was reacted with 30 ml of 40% hydrobromic acid at 150° C. for 7 hours with stirring. The reaction solution was cooled and added with 20 ml of chloroform, and then the hydrobromic acid layer was separated from the chloroform layer. The hydrobromic acid was removed under reduced pressure and the residue was recrystallized from 5 ml of ethyl alcohol to give 4.46 g of 1-methyl-3-bromopropyldimethylamine hydrobromide in a yield of 79%.

후처리

  1. temperatureThe reaction solution was cooled
  2. customthe hydrobromic acid layer was separated from the chloroform layer
  3. customThe hydrobromic acid was removed under reduced pressure
  4. customthe residue was recrystallized from 5 ml of ethyl alcohol

출처 및 근거

ORD 기록
ord-ecee95e405c641be9d7c793c11162d63
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04533731

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