Hydrochloric Acid → 1-phenyl-1H-pyrazol-5-ol

HRID 485680노트

반응식

HRID 485680 반응식
C(OC([C:6]1[C:10](=[O:11])[N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[NH:8][CH:7]=1)=O)C.Cl>[OH-].[Na+]>[C:12]1([N:9]2[C:10](=[O:11])[CH:6]=[CH:7][NH:8]2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 223722Ethyl 3-oxo-2-phenyl-2,3-dihydro-1h-pyrazole-4-carboxylate

생성물 1

HCID 27487101-phenyl-1H-pyrazol-5-ol수율 72.7%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

4-Ethoxycarbonyl-1-phenyl-3-pyrazolin-5-one (2.139 g, 9.2 mmol) in 1N sodium hydroxide (50 ml) was stirred under nitrogen at vigorous reflux for three hours. The reaction mixture was allowed to cool and acidified (HCl) to pH 3.5, whereupon ethyl acetate extraction, followed by drying (MgSO4) and evaporation produced the desired product (1.072 g, 72%) δ max(CHCl3) 1705, 1595, 1495 cm-1 δ(D6 -DMSO) 5.60 (1H,d,J2 Hz, C4 proton), 7.60 (6H, m, phenyl protons and C3 proton) Found; M+ ; 160.0641. C9H8N2O6 requires M; 160.0637.

후처리

  1. temperatureat vigorous reflux for three hours
  2. temperatureto cool
  3. extractionwhereupon ethyl acetate extraction
  4. customby drying
  5. custom(MgSO4) and evaporation

출처 및 근거

ORD 기록
ord-e552ae1ab9a741ab8e60d2c0b06aecd9
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04537886

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