Acetyl chloride → 1-(2,4-Dimethoxyphenyl)ethanone

HRID 486422

반응식

HRID 486422 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[CH:4]=1.[C:11](Cl)(=[O:13])[CH3:12].[Cl-].[Al+3].[Cl-].[Cl-]>C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([O:9][CH3:10])[CH:6]=[CH:7][C:8]=1[C:11](=[O:13])[CH3:12]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 90251,3-DimethoxybenzeneHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 700161-(2,4-Dimethoxyphenyl)ethanone

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Using a Perrier modification, Perrier, Chem. Ber., Vol. 33, pp. 819 et seq. (1900), and Perrier, Bull. Soc. Chim. France, pp. 859 et seq. (1904), 1,3-dimethoxybenzene (138.0 g) (which may be obtained from Aldrich Chemical Company, Inc., Milwaukee, Wis.) is reacted with acetyl chloride (72.0 g), methylene chloride (500 ml), and aluminum chloride (145.0 g) to provide 2',4'-dimethoxy-acetophenone, which may then be purified using standard vacuum fractional distillation.

출처 및 근거

ORD 기록
ord-ba47e44c9a6a4cb5a071b3c192b07bc6
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05292719

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