1,2-Dichloro-4-nitrobenzene → 3,4-dichloro-N-(propan-2-yl)aniline

HRID 486967노트

반응식

HRID 486967 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([N+:9]([O-])=O)[CH:5]=[CH:6][C:7]=1[Cl:8].C(O[CH2:16][CH2:17][CH2:18]C)(=O)C>[Pt]>[CH:17]([NH:9][C:4]1[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=1)([CH3:18])[CH3:16]

참가 물질

4

반응물 2

HCID 74431,2-Dichloro-4-nitrobenzeneHCID 31272Butyl Acetate

생성물 1

HCID 138030173,4-dichloro-N-(propan-2-yl)aniline수율 84.5%

시약·촉매·용매 1

HCID 23939Platinum촉매

실험 절차

480.0 g (2.5 mol) of 3,4-dichloronitrobenzene were reacted in 2500 ml of butyl acetate under the reaction conditions described in Example 1 with 10 g of sulfited platinum catalyst F1OP. After the solvent had been distilled off in vacuo, the residue was fractionated to give 431.0 g of N-isopropyl-3,4-dichloroaniline at a purity of 98.9% (GC) in the boiling range 143° to 148° C. (13.33 to 16 bar), which corresponds to a yield of 84.5% of theory.

후처리

  1. distillationAfter the solvent had been distilled off in vacuo

출처 및 근거

ORD 기록
ord-e8e065b02ab740ee9aba937af52c2188
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05292957

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