Hydrochloric Acid → 4-Tert-butyl-2-[5-(2-carboxyphenylmethoxy)benzofuran-2-yl]thiazole

HRID 487684노트

반응식

HRID 487684 반응식
[C:1]([C:5]1[N:6]=[C:7]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([O:19][CH2:20][C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=4[C:27]([O:29]C)=[O:28])=[CH:15][C:13]=3[CH:14]=2)[S:8][CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].Cl>CO.O>[C:1]([C:5]1[N:6]=[C:7]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([O:19][CH2:20][C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=4[C:27]([OH:29])=[O:28])=[CH:15][C:13]=3[CH:14]=2)[S:8][CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 190927604-Tert-butyl-2-[5-(2-methoxycarbonylphenylmethoxy)benzofuran-2-yl]thiazole

생성물 1

HCID 190927584-Tert-butyl-2-[5-(2-carboxyphenylmethoxy)benzofuran-2-yl]thiazole수율 99.7%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A mixture of 4-tert-butyl-2-[5-(2-methoxycarbonylphenylmethoxy)benzofuran-2-yl]thiazole (0.28 g) and 4N aqueous sodium hydroxide (1.0 ml) in methanol (5 ml) was stirred under reflux 5.5 hours. After being cooled, the resulting solution was concentrated under reduced pressure to give a residue. The residue was dissolved in water and adjusted to pH 4 with diluted aqueous hydrochloric acid to give crystals. The crystals were filtered and washed with water to give 4-tert-butyl-2-[5-(2-carboxyphenylmethoxy)benzofuran-2-yl]thiazole (0.27 g).

후처리

  1. temperatureunder reflux 5.5 hours
  2. temperatureAfter being cooled
  3. concentrationthe resulting solution was concentrated under reduced pressure
  4. customto give a residue
  5. customto give crystals
  6. filtrationThe crystals were filtered
  7. washwashed with water

출처 및 근거

ORD 기록
ord-18c47e5cef6e4ad7b27097a6505279fd
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05296495

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