Hydrochloric Acid → 3-Amino-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid

HRID 487724노트

반응식

HRID 487724 반응식
[OH-].[Na+].C([N:6]1[CH2:11][CH2:10][C:9]2[S:12][C:13]([C:16]([O:18]C)=[O:17])=[C:14]([NH2:15])[C:8]=2[CH2:7]1)(=O)C.Cl>O>[NH2:15][C:14]1[C:8]2[CH2:7][NH:6][CH2:11][CH2:10][C:9]=2[S:12][C:13]=1[C:16]([OH:18])=[O:17]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19093041HCID 19093041, 화합물

생성물 1

HCID 190930483-Amino-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid수율 38%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

An aqueous solution obtained by dissolving 9.1 g of sodium hydroxide in 90 ml of water was added to 5.8 g (46%) of methyl 5-acetyl-3-amino-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2carboxylate (Compound No. 16) obtained in Example 1 and the resultant mixture was heated under reflux for 2 hours. After cooling followed by neutralization with concentrated hydro-chloric acid, the solvent was distilled off. Methanol was added to the residue and the crystals thus formed were taken by filtration and thoroughly washed with water to obtain 1.7 g of 3-amino-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid. Yield: 38%.

후처리

  1. customAn aqueous solution obtained
  2. custom16) obtained in Example 1
  3. temperatureunder reflux for 2 hours
  4. temperatureAfter cooling
  5. distillationthe solvent was distilled off
  6. additionMethanol was added to the residue
  7. customthe crystals thus formed
  8. filtrationwere taken by filtration
  9. washthoroughly washed with water

출처 및 근거

ORD 기록
ord-a3579ee4f44d431d939910645b17cdb5
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05296603

반응 노트

불러오는 중…