1,3-Propanediamine → N-(2-Methyl-5-thiazolylmethyl]trimethylenediamine
반응식
[NH2:1][CH2:2][CH2:3][CH2:4][NH2:5].Cl[CH2:7][C:8]1[S:12][C:11]([CH3:13])=[N:10][CH:9]=1.[OH-].[Na+]>C(#N)C>[CH3:13][C:11]1[S:12][C:8]([CH2:7][NH:1][CH2:2][CH2:3][CH2:4][NH2:5])=[CH:9][N:10]=1참가 물질
5
실험 절차
Trimethylenediamine (37 g) was dissolved in 120 ml of acetonitrile, and a solution of 14.8 g of 5-chloromethyl-2-methylthiazole in 30 ml of acetonitrile was added dropwise at 10° to 15° C. After the addition, the mixture was stirred at 30° to 40° C. for a while, and then 8 g of a 50% aqueous solution of sodium hydroxide was added. Subsequently, the volatile materials were removed at a bath temperature of less than 50° C. under 5 mmHg. The inorganic materials were removed from the residue by filtration to give 16.7 g of N-(2-methyl-5-thiazolylmethyl)trimethylenediamine (purity about 90%) as a colorless oil.
후처리
- additionAfter the addition
- customSubsequently, the volatile materials were removed at a bath temperature of less than 50° C. under 5 mmHg
- customThe inorganic materials were removed from the residue by filtration
출처 및 근거
- ORD 기록
- ord-da1d7e3f9c3f49888077587bc385028d
- 출처 데이터셋
- uspto-grants-1994_03
- 특허 번호
- US05298507
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