O-Xylene → 4-Propylpyridin-2-amine

HRID 487999

반응식

HRID 487999 반응식
[CH2:1]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1)[CH2:2][CH3:3].[NH2-:10].[Na+].C1(C)C(C)=CC=CC=1>O>[NH2:10][C:6]1[CH:5]=[C:4]([CH2:1][CH2:2][CH3:3])[CH:9]=[CH:8][N:7]=1

참가 물질

5

반응물 3

HCID 7237O-XyleneHCID 24533Sodium amide2회HCID 707384-Propylpyridine

생성물 1

HCID 70225944-Propylpyridin-2-amine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

75 g (0.62M) of 4-n-propylpyridine and 28 g (0.73M) of sodium amide were added to 250 ml of xylene, and the mixture was heated under reflux for 10 hr. Water was added in small portions to the reaction mixture under ice cooling to decompose excess sodium amide, and the reaction mixture was extracted with ethyl acetate, dried over magnesium sulfate and then purified by column chromatography (dichloromethanemethanol 50:1→20:1). The yield was 33 g. (blackish purple solid)

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 10 hr
  3. extractionthe reaction mixture was extracted with ethyl acetate
  4. dry with materialdried over magnesium sulfate
  5. custompurified by column chromatography (dichloromethanemethanol 50:1→20:1)

출처 및 근거

ORD 기록
ord-99275caca2504d5a8f8480478f041851
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05298518

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