Sulfuric Acid → 2-hydroxyimino-N-phenylacetamide
반응식
[C:1]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)(=[O:6])[CH2:2]C(C)=O.[N:14]([O-])=[O:15].[Na+].S(=O)(=O)(O)O>[OH-].[Na+]>[OH:15][N:14]=[CH:2][C:1]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:6]참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
Acetoacetanilide (25.0 g, 0.14 mol) and sodium nitrite (12.65 g, 0.18 mol) were dissolved in aqueous sodium hydroxide solution (140 ml, 1 N) and the resulting solution was added dropwise over 20 min to an aqueous solution of sulfuric acid (120 ml conc. H2SO4 in 950 ml water) cooled in an ice bath. The reaction mixture was stirred at 0° C. for 30 min, then the precipitate was filtered and washed with water to yield 2-hydroxyiminoacetanilide (22.64 g., 78% yield) as a pale yellow solid.
후처리
- temperaturecooled in an ice bath
- filtrationthe precipitate was filtered
- washwashed with water
출처 및 근거
- ORD 기록
- ord-abc6f84208b84ffcba07207732b9c7ba
- 출처 데이터셋
- uspto-grants-2005_12
- 특허 번호
- US06974813B2
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