Hydrochloric Acid → 1,2-Benzisothiazole-3-carboxylic acid

HRID 48990

반응식

HRID 48990 반응식
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([C:10](N)=[O:11])=[N:2]1.[OH-:13].[Na+].Cl>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([C:10]([OH:11])=[O:13])=[N:2]1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 156394701,2-Benzothiazole-3-carboxamide

생성물 1

HCID 945121,2-Benzisothiazole-3-carboxylic acid수율 96%

실험 절차

A mixture of 1,2-benzisothiazole-3-carboxamide (5.0 g, 0.028 mole) and 1N aqueous sodium hydroxide (55 ml) is heated on a steam bath until solution is achieved (approximately 30 minutes), cooled to room temperature, and acidified with 2N hydrochloric acid. The resulting precipitate is filtered and dried in vacuo to afford the title compound (1.85 g, 96%) as a white solid, which is identified by NMR and IR spectral analysis.

후처리

  1. temperatureis heated on a steam bath until solution
  2. custom(approximately 30 minutes)
  3. filtrationThe resulting precipitate is filtered
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-799d51a894f9464c914a010d58fc72da
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06706663B2

연결된 노트

불러오는 중…