Hydrochloric Acid → 4-Isopropyl-2-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid

HRID 490710노트

반응식

HRID 490710 반응식
C([O:3][C:4]([C:6]1[S:10][C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)=[N:8][C:7]=1[CH:21]([CH3:23])[CH3:22])=[O:5])C.[OH-].[Na+].Cl>C1COCC1>[CH:21]([C:7]1[N:8]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:19])([F:20])[F:18])=[CH:13][CH:12]=2)[S:10][C:6]=1[C:4]([OH:5])=[O:3])([CH3:23])[CH3:22]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 587658244-Isopropyl-2-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid ethyl ester

생성물 1

HCID 589340934-Isopropyl-2-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
70 °C

실험 절차

To a solution of 4-isopropyl-2-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid ethyl ester (0.62 g, 1.80 mmol) in THF (10 mL) is added 5M NaOH (3.5 mL, 17.50 mmol). The mixture is heated at 70° C. for 12 h. Upon cooling to RT, the mixture is acidified with 5M HCl and extracted with EtOAc. The organics are washed with water and brine, and dried with MgSO4. After concentration, the title compound is obtained (0.46 g, 81%). The material is used without further purification.

후처리

  1. temperatureUpon cooling to RT
  2. extractionextracted with EtOAc
  3. washThe organics are washed with water and brine
  4. dry with materialdried with MgSO4
  5. concentrationAfter concentration

출처 및 근거

ORD 기록
ord-9667c60aea1d46ae8d21f8ef57d229a4
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07528160B2

반응 노트

불러오는 중…