3-Fluorophenol → 3-(3-Fluorophenoxy)propanoic acid
반응식
[F:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.Br[CH2:10][CH2:11][C:12]([OH:14])=[O:13].[OH-].[Na+]>O>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][CH:7]=1)[O:8][CH2:10][CH2:11][C:12]([OH:14])=[O:13]참가 물질
5
실험 절차
3-Fluorophenol (8.9 g, 79.5 mmol) and 3-bromopropionic acid (12.24 g, 80.0 mmol) were placed in a flask. A solution of NaOH (6.7 g, 167 mmol) in 20 mL water was added slowly to the flask. The reaction mixture was heated to reflux for two hours and then cooled to room temperature and partitioned between ethyl acetate and water. The organic layer was dried over MgSO4, and solvent was evaporated under reduced pressure to give 4.57 g (25 mmol, 31.4%) of 3-(3-fluoro-phenoxy)-propionic acid. MS: 185 (M+H)+.
후처리
- temperatureThe reaction mixture was heated
- temperatureto reflux for two hours
- custompartitioned between ethyl acetate and water
- dry with materialThe organic layer was dried over MgSO4, and solvent
- customwas evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-8e3df580c6a841e6a6a0593fac2ce51a
- 출처 데이터셋
- uspto-grants-2009_05
- 특허 번호
- US07528250B2
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