Hydrochloric Acid → (3-((Methylsulfonyl)amino)phenyl)acetic acid

HRID 491538노트

반응식

HRID 491538 반응식
[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[C:8]([CH2:12][C:13]([O:15]C)=[O:14])[CH:9]=[CH:10][CH:11]=1)(=[O:4])=[O:3].[OH-].[Na+].Cl.O>C(O)C>[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[C:8]([CH2:12][C:13]([OH:15])=[O:14])[CH:9]=[CH:10][CH:11]=1)(=[O:4])=[O:3]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 21071300Methyl 3-(methanesulfonylamino)phenylacetate

생성물 1

HCID 2773885(3-((Methylsulfonyl)amino)phenyl)acetic acid수율 92%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Methyl 3-(methanesulfonylamino)phenylacetate (3.36 g, 13.8 mmol) was dissolved in ethanol (16 mL) and 1N NaOH (30 mL) added. The reaction was stirred for 1 hour, then 1N HCl (50 mL) and water (50 mL) were added. The product was extracted into ethyl acetate (3×50 mL) and the combined extracts were washed with water and brine and dried (MgSO4). Removal of solvent afforded 3-(methanesulfonylamino)phenylacetic acid (2.90 g, 92%). 1H NMR (DMSO-6) δ 12.32 (1H, br), 9.69 (1H, br), 7.26 (1H, dd), 7.10 (2H, m), 7.00 (1H, d), 6.57 (1H, s), 3.54 (2H, s), 2.97 (3H, s).

후처리

  1. extractionThe product was extracted into ethyl acetate (3×50 mL)
  2. washthe combined extracts were washed with water and brine
  3. dry with materialdried (MgSO4)
  4. customRemoval of solvent

출처 및 근거

ORD 기록
ord-282cd812abd84317a7db81e210843cb3
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07531556B2

반응 노트

불러오는 중…