Hydrochloric Acid → 2,3-Difluoro-4-methoxybenzoic acid

HRID 491732노트

반응식

HRID 491732 반응식
[OH-].[Na+].[F:3][C:4]1[C:13]([F:14])=[C:12]([O:15][CH3:16])[CH:11]=[CH:10][C:5]=1[C:6]([O:8]C)=[O:7].C1COCC1.Cl>CO>[F:3][C:4]1[C:13]([F:14])=[C:12]([O:15][CH3:16])[CH:11]=[CH:10][C:5]=1[C:6]([OH:8])=[O:7]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 21907384Methyl 2,3-difluoro-4-methoxybenzoate

생성물 1

HCID 36116822,3-Difluoro-4-methoxybenzoic acid수율 96%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Sodium hydroxide (2N, 50 mL) was added into a mixture of methyl 2,3-difluoro-4-methoxybenzoate (10.0 g, 49.5 mmol), THF (100 mL) and MeOH (100 mL). The mixture was stirred at room temperature for 6 h, and acidified with HCl (2N). The precipitated solid was filtered off, washed with water and dried to give a white solid (8.9 g, 96% yield, m.p. 194-196° C.); MS m/e 187 (M−H)+.

후처리

  1. filtrationThe precipitated solid was filtered off
  2. washwashed with water
  3. customdried

출처 및 근거

ORD 기록
ord-b40aca0eecba41b9ab3db83e46e20cdc
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07531564B2

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