Sodium hydride → 2-{[2-(Allyloxy)-4-(benzyloxy)phenoxy]methyl}oxirane

HRID 49248

반응식

HRID 49248 반응식
[H-].[Na+].[CH2:3]([O:6][C:7]1[CH:12]=[C:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:10]=[CH:9][C:8]=1[OH:21])[CH:4]=[CH2:5].CC1C=CC(S(O[CH2:33][C@@H:34]2[O:36][CH2:35]2)(=O)=O)=CC=1>CCCCCC.CN(C)C=O>[CH2:3]([O:6][C:7]1[CH:12]=[C:11]([O:13][CH2:14][C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:10]=[CH:9][C:8]=1[O:21][CH2:33][CH:34]1[CH2:35][O:36]1)[CH:4]=[CH2:5]

참가 물질

6

반응물 3

HCID 24758Sodium hydrideHCID 154187Glycidyl tosylate, (R)-HCID 185460122-Allyloxy-4-(benzyloxy)phenol

생성물 1

HCID 185460222-{[2-(Allyloxy)-4-(benzyloxy)phenoxy]methyl}oxirane

시약·촉매·용매 2

HCID 6228Dimethylformamide용매2회HCID 8058Hexane용매

실험 절차

Sodium hydride (4.3 g, 0.11 mole of 60% mineral oil dispersion) was washed with hexane and suspended in 100 mL of N,N-dimethylformamide. To this suspension was added a solution of 25.4 g (0.10 mole) of 2-allyloxy-4-(benzyloxy)phenol in 100 mL of DMF. The mixture was stirred at room temperature for 30 minutes and then 22.8 g (0.10 mole) of (2R)-(−)-glycidyl tosylate was added.

출처 및 근거

ORD 기록
ord-6233de2de6f143688edd4dcfaa46e9b9
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06706736B2

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