Vanillin → (4E)-2-(1,3-benzothiazol-2-yl)-4-{[4-hydroxy-3-(methyloxy)phenyl]-methylidene}-5-methyl-2,4-dihydro-3H-pyrazol-3-one

HRID 493011

반응식

HRID 493011 반응식
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[N:10]1[C:14](=[O:15])[CH2:13][C:12]([CH3:16])=[N:11]1.[OH:17][C:18]1[CH:25]=[CH:24][C:21]([CH:22]=O)=[CH:20][C:19]=1[O:26][CH3:27].N1CCCCC1>C(O)C.O>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[N:10]1[C:14](=[O:15])/[C:13](=[CH:22]/[C:21]2[CH:24]=[CH:25][C:18]([OH:17])=[C:19]([O:26][CH3:27])[CH:20]=2)/[C:12]([CH3:16])=[N:11]1

참가 물질

6

반응물 3

HCID 1183VanillinHCID 8082PiperidineHCID 459449Pyrazol-5(4H)-one, 1-(2-benzothiazolyl)-3-methyl-

생성물 1

HCID 136385044(4E)-2-(1,3-benzothiazol-2-yl)-4-{[4-hydroxy-3-(methyloxy)phenyl]-methylidene}-5-methyl-2,4-dihydro-3H-pyrazol-3-one

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

1 g (4.32 mmol) of 2-(1,3-benzothiazol-2-yl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one and 1.97 g (12.96 mmol) of 4-hydroxy-3-methoxybenzaldehyde are stirred under reflux with the addition of 3 ml of piperidine in absolute ethanol for 2 hours. The mixture is then diluted with water and the orange-yellow precipitate is filtered off, then washed with water and a small amount of cold methanol and dried under reduced pressure.

후처리

  1. filtrationthe orange-yellow precipitate is filtered off
  2. washwashed with water
  3. dry with materiala small amount of cold methanol and dried under reduced pressure

출처 및 근거

ORD 기록
ord-05cff674b3534b0793ca50617ff8a74e
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07534273B2

연결된 노트

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