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Hydrochloric Acid → 1-[4-(Tert-butoxycarbonyl)phenyl]-2-(4-n-propylphenyl)acetylene

HRID 493043
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인쇄 미리보기

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HRID 493043 반응식
C([C:5]1([CH:13]=[CH:12][C:11](Br)=[CH:10][CH2:9]1)[C:6]([O-:8])=[O:7])(C)(C)C.[CH2:15]([C:18]1[CH:23]=[CH:22][C:21]([C:24]#[CH:25])=[CH:20][CH:19]=1)[CH2:16][CH3:17].[CH2:26]([C:29]1[CH:34]=CC(Br)=C[CH:30]=1)CC.C[Si](C#C)(C)C.Cl>O>[C:29]([O:8][C:6]([C:5]1[CH:9]=[CH:10][C:11]([C:25]#[C:24][C:21]2[CH:20]=[CH:19][C:18]([CH2:15][CH2:16][CH3:17])=[CH:23][CH:22]=2)=[CH:12][CH:13]=1)=[O:7])([CH3:34])([CH3:30])[CH3:26]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 66111TrimethylsilylacetyleneHCID 1363741-Bromo-4-propylbenzeneHCID 27751331-Ethynyl-4-propylbenzeneHCID 229258901-Tert-butyl-4-bromobenzoate

생성물 1

HCID 229257481-[4-(Tert-butoxycarbonyl)phenyl]-2-(4-n-propylphenyl)acetylene

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The reaction was conducted in the same manner as in the step (i) of the Example 31, except for using 1-tert-butyl-4-bromobenzoate synthesized in the step (i) of the Example 106 and 4-n-propylphenylacetylene synthesized in the step (ii) of the Example 31 instead of 1-n-propyl-4-bromobenzene and trimethylsilylacetylene, respectively. After completion of the reaction, the reaction mixture was poured into an iced water, and the resultant mixture was acidified by adding hydrochloric acid. The resultant solid was collected by filtration, washed with water, dried, and recrystallized from hexane to give 1-[4-(tert-butoxycarbonyl)phenyl]-2-(4-n-propylphenyl)acetylene.

후처리

  1. customAfter completion of the reaction
  2. filtrationThe resultant solid was collected by filtration
  3. washwashed with water
  4. customdried
  5. customrecrystallized from hexane

출처 및 근거

ORD 기록
ord-e7498c6b1f4643c78c2a73573bceed37
출처 데이터셋
uspto-grants-2009_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07534547B2

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