Erythrose, 4-phosphate → D-erythritol 4-phosphate

HRID 493052노트

반응식

HRID 493052 반응식
[Na].[P:2]([O:6][CH2:7][C@@H:8]([OH:13])[C@@H:9]([OH:12])[CH:10]=[O:11])([OH:5])([OH:4])=[O:3].[BH4-].[Na+]>CO>[P:2]([O:6][CH2:7][C@@H:8]([OH:13])[C@@H:9]([OH:12])[CH2:10][OH:11])([OH:4])([OH:5])=[O:3]

참가 물질

5

반응물 3

HCID 122357Erythrose, 4-phosphateHCID 4311764Sodium borohydrideHCID 5360545Sodium

생성물 1

HCID 192838D-erythritol 4-phosphate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The sodium salt of D-erythrose 4-phosphate (14.6 mg, 65.7 pmol) is dissolved in methanol (600 μl, 40% (v/v)). Sodium borohydride is added. The reaction is monitored by detection of the aldehyde according to the method of Stahl (Bollinger, H. R., Brenner, M., Gänshirt, H., Mangold, H. K., Seiler, H., Stahl, E. ad Waldi, D. (1964) IN: Dünnschicht-Chromatographie; Ein Laboratoriumshandbuch (ed. Stahl, E.) Springer Verlag, Berlin, Göttingen; Heidelberg). After consumption of the aldehyde the pH of the solution is adjusted with acetic acid to 4-5. The reaction mixture is lyophillized yielding D-erythritol 4-phosphate as a dry compound.

후처리

  1. customAfter consumption of the aldehyde the pH of the solution

출처 및 근거

ORD 기록
ord-e425671040d64d4bbd0b13029651ea37
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07534742B2

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